2016-10
2019-09
2019-10
86
NCT02335151
University of Zurich
University of Zurich
INTERVENTIONAL
CTC Pancreatic Adenocarcinoma
Proportion of circulating tumor cells (CTC) in the postoperative phase after curative tumor removal of pancreatic cancer will be determined and correlated to the accordance of anesthesia (desflurane versus propofol)
This prospective, randomized study will be conducted over a 36-month period to investigate whether commonly used anesthetics (volatile versus intravenous) have an effect on the changes or occurrence of CTC in patients suffering from primary pancreatic cancer undergoing curative surgery. The specific research question is if there are changes of the CTC count in the postoperative phase in the desflurane group (intervention) compared to the propofol one (control). A secondary question is if these changes can be correlated to tumor outcome.
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
| Study Registration Dates | Results Reporting Dates | Study Record Updates |
|---|---|---|
2014-12-13 | N/A | 2019-12-12 |
2015-01-08 | N/A | 2019-12-13 |
2015-01-09 | N/A | 2019-12 |
This section provides details of the study plan, including how the study is designed and what the study is measuring.
Primary Purpose:
Treatment
Allocation:
Randomized
Interventional Model:
Parallel
Masking:
Double
Arms and Interventions
| Participant Group/Arm | Intervention/Treatment |
|---|---|
| EXPERIMENTAL: Desflurane General anesthesia with Desflurane | DRUG: Desflurane
|
| NO_INTERVENTION: Propofol General anesthesia with Propofol |
| Primary Outcome Measures | Measure Description | Time Frame |
|---|---|---|
| Peak of CTC in the postoperative phase after curative tumor removal | CTC will be counted and peak of CTC will be determined. | Day 0 to Day 7 |
| Secondary Outcome Measures | Measure Description | Time Frame |
|---|---|---|
| Kinetics of CTC after surgery up to day 7 | CTC will be counted and kinetics of CTC will be determined. | 1 year |
| Month to Tumor recurrence | Tumor recurrence will be monitored. | 1 year |
| Number of surviving patients | One year after surgery the number of patients still being alive will be determined. | 1 year |
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person’s general health condition or prior treatments.
Ages Eligible for Study:
ALL
Sexes Eligible for Study:
18 Years
Accepts Healthy Volunteers:
This is where you will find people and organizations involved with this study.
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
No publications available
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