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2025-07-29
2026-12-29
2026-12-29
168
NCT07091526
Hepatopancreatobiliary Surgery Institute of Gansu Province
Hepatopancreatobiliary Surgery Institute of Gansu Province
OBSERVATIONAL
Whether Control of Serum Uric Acid (SUA) Improves Survival After Pancreatic Cancer
This retrospective study aims to analyze the impact of postoperative changes in serum uric acid (SUA) levels on the prognosis of patients undergoing pancreatic cancer resection.
Serum uric acid is a risk factor for gallbladder cancer in men and has a strong effect on pancreatic cancer in women. It has also been shown that elevated intracellular serum uric acid can induce an inflammatory stress response, which may promote its transformation, while elevated extracellular serum uric acidy further stimulate tumor cell proliferation, migration, and survival, and promote the development of highly aggressive cancer. In this study, the changes of serum uric acid before and after surgery was used as a prognostic marker for the survival of pancreatic cancer patients.
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
| Study Registration Dates | Results Reporting Dates | Study Record Updates |
|---|---|---|
2025-07-21 | N/A | 2025-07-21 |
2025-07-21 | N/A | 2025-07-29 |
2025-07-29 | N/A | 2025-07 |
This section provides details of the study plan, including how the study is designed and what the study is measuring.
Primary Purpose:
N/A
Allocation:
N/A
Interventional Model:
N/A
Masking:
N/A
Arms and Interventions
| Participant Group/Arm | Intervention/Treatment |
|---|---|
| : High serum uric acid The increase of after serum uric acid operation compared with that before operation is≥10% Normal levels serum uric acid are typically 178 to 360 μm (3 to 6.8 mg/dl). | DIAGNOSTIC_TEST: serum uric acid test
|
| : Low serum uric acid The increase of after serum uric acid operation compared with that before operation < 10% Normal serum uric acid levels are typically 178 to 360 μm (3 to 6.8 mg/dl). | DIAGNOSTIC_TEST: serum uric acid test
|
| Primary Outcome Measures | Measure Description | Time Frame |
|---|---|---|
| Overall survival | Overall survival was defined as the time from diagnosis to death. | 3-5 years |
| Secondary Outcome Measures | Measure Description | Time Frame |
|---|---|---|
| Recurrence-free survival | Recurrence-free survival is the length of time from either the date of diagnosis or the start of therapy for a disease to the date of the first loco-regional or systemic recurrence. | 3-5 years |
| Cost of hospitalization | The cost of the first hospitalization from admission to discharge. | 3 months |
| Length of hospital stay | The first day of hospitalization for the first admission to the last day of discharge. | 3 months |
| Pancreatic fistula | Whether or not pancreatic-intestinal anastomotic leakage occurred at the time of the first hospitalization. | 3 months |
| Biliary fistula | Whether or not a biliary-intestinal anastomotic leak occurred at the time of the first hospitalization. | 3 months |
| Bleeding | Whether or not there was bleeding after the first inpatient surgery. | 3 months |
| Abdominal cavity infection | Whether or not there was an abdominal infection after the first inpatient surgery. | 3 months |
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
|
Study Contact Name: Wenbo Meng, M.D. Ph. D. Phone Number: 13919177177 Email: mengwb@163.com |
Study Contact Backup Name: Zhengping An, M.D. Phone Number: 18298415512 Email: anzhp2023@lzu.edu.cn |
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person’s general health condition or prior treatments.
Ages Eligible for Study:
ALL
Sexes Eligible for Study:
18 Years
Accepts Healthy Volunteers:
This is where you will find people and organizations involved with this study.
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
