Temsirolimus And Bevacizumab In Treating Patients With Advanced Endometrial, Ovarian, Liver, Carcinoid, Or Islet Cell Cancer

Study Overview

Temsirolimus and Bevacizumab in Treating Patients With Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell Cancer

This phase II trial studies how well temsirolimus and bevacizumab work in treating patients with advanced endometrial, ovarian, liver, carcinoid, or islet cell cancer. Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of cancer by blocking blood flow to the tumor. Giving temsirolimus together with bevacizumab may kill more tumor cells.

PRIMARY OBJECTIVES: I. To determine the response rate and progression-free survival at 6 months in patients with endometrial, ovarian, hepatocellular carcinoma, carcinoid or islet cell cancer. II. To determine the toxicity of the combination of temsirolimus and bevacizumab in patients with endometrial, ovarian, hepatocellular carcinoma, carcinoid or islet cell cancer. SECONDARY OBJECTIVES: I. To collect blood and tumor specimens from all patients entered on the trial for possible future analysis. OUTLINE: Patients receive temsirolimus intravenously (IV) on days 1, 8, 15, and 22, and bevacizumab IV over 30-90 minutes on days 1 and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up for 3 years.

Adult Hepatocellular Carcinoma
Advanced Adult Hepatocellular Carcinoma
Endometrial Serous Adenocarcinoma
Localized Non-Resectable Adult Liver Carcinoma
Lung Carcinoid Tumor
Malignant Pancreatic Gastrinoma
Malignant Pancreatic Glucagonoma
Malignant Pancreatic Insulinoma
Malignant Pancreatic Somatostatinoma
Metastatic Digestive System Neuroendocrine Tumor G1
Ovarian Carcinosarcoma
Ovarian Endometrioid Adenocarcinoma
Ovarian Seromucinous Carcinoma
Ovarian Serous Surface Papillary Adenocarcinoma
Pancreatic Alpha Cell Adenoma
Pancreatic Beta Cell Adenoma
Pancreatic Delta Cell Adenoma
Pancreatic G-Cell Adenoma
Pancreatic Polypeptide Tumor
Recurrent Adult Liver Carcinoma
Recurrent Digestive System Neuroendocrine Tumor G1
Recurrent Fallopian Tube Carcinoma
Recurrent Ovarian Carcinoma
Recurrent Pancreatic Neuroendocrine Carcinoma
Recurrent Primary Peritoneal Carcinoma
Recurrent Uterine Corpus Carcinoma
Regional Digestive System Neuroendocrine Tumor G1
Stage IIIA Fallopian Tube Cancer
Stage IIIA Ovarian Cancer
Stage IIIA Primary Peritoneal Cancer
Stage IIIA Uterine Corpus Cancer
Stage IIIB Fallopian Tube Cancer
Stage IIIB Ovarian Cancer
Stage IIIB Primary Peritoneal Cancer
Stage IIIB Uterine Corpus Cancer
Stage IIIC Fallopian Tube Cancer
Stage IIIC Ovarian Cancer
Stage IIIC Primary Peritoneal Cancer
Stage IIIC Uterine Corpus Cancer
Stage IV Fallopian Tube Cancer
Stage IV Ovarian Cancer
Stage IV Primary Peritoneal Cancer
Stage IVA Uterine Corpus Cancer
Stage IVB Uterine Corpus Cancer
Uterine Carcinosarcoma

BIOLOGICAL: Bevacizumab
DRUG: Temsirolimus

NCI-2012-02086
NCI-2012-02086 (REGISTRY Identifier) (REGISTRY: CTRP (Clinical Trial Reporting Program))
NCI-2011-02504
MC0845
CDR0000653790
NCI-2012-01049
8233 (OTHER Identifier) (OTHER: Mayo Clinic)
8233 (OTHER Identifier) (OTHER: CTEP)
N01CM00032 (U.S. NIH Grant/Contract)
N01CM00038 (U.S. NIH Grant/Contract)
N01CM00039 (U.S. NIH Grant/Contract)
N01CM00070 (U.S. NIH Grant/Contract)
N01CM00071 (U.S. NIH Grant/Contract)
N01CM00099 (U.S. NIH Grant/Contract)
N01CM00100 (U.S. NIH Grant/Contract)
N01CM62201 (U.S. NIH Grant/Contract)
N01CM62203 (U.S. NIH Grant/Contract)
N01CM62204 (U.S. NIH Grant/Contract)
N01CM62205 (U.S. NIH Grant/Contract)
N01CM62206 (U.S. NIH Grant/Contract)
N01CM62207 (U.S. NIH Grant/Contract)
N01CM62208 (U.S. NIH Grant/Contract)
N01CM62209 (U.S. NIH Grant/Contract)
P30CA015083 (U.S. NIH Grant/Contract)
P50CA102701 (U.S. NIH Grant/Contract)

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates	Results Reporting Dates	Study Record Updates
First Submitted 2009-11-06	Results First Submitted 2018-09-20	Last Update Submitted that met QC Criteria 2019-01-24
First Submitted that Met QC Criteria 2009-11-06	Results First Submitted that Met QC Criteria 2019-01-24	Last Update Posted (ACTUAL) 2019-01-25
First Posted (ACTUAL) 2009-11-09	Results First Posted 2019-01-25	Last Verified 2019-01

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

Primary Purpose:
Treatment

Allocation:
Na

Interventional Model:
Single Group

Masking:
None

Arms and Interventions

Participant Group/Arm	Intervention/Treatment
EXPERIMENTAL: Treatment (temsirolimus, bevacizumab) Patients receive temsirolimus IV on days 1, 8, 15, and 22, and bevacizumab IV over 30-90 minutes on days 1 and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.	BIOLOGICAL: Bevacizumab Given IV DRUG: Temsirolimus Given IV

Participant Group/Arm

Intervention/Treatment

EXPERIMENTAL: Treatment (temsirolimus, bevacizumab)

Patients receive temsirolimus IV on days 1, 8, 15, and 22, and bevacizumab IV over 30-90 minutes on days 1 and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

BIOLOGICAL: Bevacizumab

Given IV

DRUG: Temsirolimus

Given IV

Primary Outcome Measures	Measure Description	Time Frame
Progression Free Survival Rate	Progression is defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0), as a 20% increase in the sum of the longest diameter of target lesions, or a measurable increase in a non-target lesion, or the appearance of new lesions. The 6-month progression free survival rate is the proportion of evaluable patients progression-free 6 months from registration. The 6-month progression-free rate is defined as the total number of efficacy evaluable patients on study without documentation of disease progression 6 months from registration divided by the total number of evaluable patients enrolled on study. Kaplan-Meier methodology will be used to estimate the final success proportion (i.e. progression free at 6 months with a 95% confidence interval).	6 months
Tumor Response Rate	Tumor response rate defined as the total number of efficacy-evaluable patients who achieved a complete or partial response according to the RECIST criteria divided by the total number of efficacy evaluable patients enrolled on study. Patients were evaluated using the Response Evaluation Criteria In Solid Tumors (RECIST) v1.1. In brief, a Complete Response (CR) means the complete disappearance of all target lesions and a reduction in each lymph node to <1 cm. A Partial Response (PR) is defined as a 30% decrease in the sum of the longest diameter of the non-nodal target lesion from baseline. Each requires no new lesions present at evaluation. The proportion of participants with a response is provided here for each cohort. The proportion was calculated as the number of patients that had a best response of CR or PR divided by the number of patients evaluated for a response in each cohort.	Up to 3 years

Secondary Outcome Measures	Measure Description	Time Frame
Duration of Response	Duration of response is defined for all evaluable patients who have achieved a response as the date at which the patient's objective status is first noted to be either a CR or PR to the date progression is documented. Objective response was assessed using Response Evaluation Criteria In Solid Tumors (RECIST) as described in Primary Objective 2 in this report. Median duration of response and the confidence interval for the median duration will be computed.	Time from date at which the patient's objective status is first noted to be either a complete response (CR) or partial response (PR) to the date progression is documented, assessed up to 3 years
Incidence of Adverse Events	Adverse events are defined as events that are classified as either possibly, probably, or definitely related to study treatment, graded per National Cancer Institute Common Terminology Criteria for Adverse Events Version 3.0. The number of patients reporting grade 3 or higher adverse events at least possibly related to treatment are reported here. For a complete list of all reported adverse events, please see the adverse events section of this report.	Every cycle of treatment, up to 3 years
Overall Survival	Survival time will be defined as the time from registration to death. Time to event distributions will be estimated using the Kaplan-Meier method.	Time from registration to death, assessed up to 3 years
Time to Disease Progression	Time to progression is defined as the time from registration to disease progression. Patients who died without documentation of progression will be considered to have progressed on the date of their death. If a patient starts treatment and fails to return for evaluation, that patient will be censored for progression of disease at day one post-registration.	Time from registration to disease progression, assessed up to 3 years
Time to Treatment Failure	Time to treatment failure is defined as the time from study entry to the date patients end treatment.Time to treatment failure will be evaluated using the method of Kaplan-Meier.	Time from study entry to the date patients end treatment, assessed up to 3 years

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person’s general health condition or prior treatments.

Ages Eligible for Study:
ALL

Sexes Eligible for Study:
18 Years

Accepts Healthy Volunteers:

Histologically or cytologically confirmed endometrial (endometrioid, uterine, papillary serous carcinoma, and carcinosarcoma), ovarian (primary peritoneal/fallopian tube, serous, endometrioid, mixed, and poorly differentiated epithelial ovarian cancers [for purposes of eligibility, carcinosarcoma is considered a poorly differentiated carcinoma]), hepatocellular carcinoma, carcinoid or islet cell (neuroendocrine: well- or moderately-differentiated neuroendocrine) cancer which are locally advanced, recurrent, or metastatic
Patients must have measurable disease; patients having only lesions measuring >= 1 cm to < 2 cm must use spiral computed tomography (CT) imaging for both pre- and post-treatment tumor assessments; patients who have had prior palliative radiotherapy to metastatic lesion(s) must have at least one measurable lesion(s) that have not been previously irradiated
Radiation therapy (adjuvant or palliative) must be completed >= 4 weeks prior to registration, if applicable
Absolute neutrophil count (ANC) >= 1500/mm^3
Platelets >= 75,000/mm^3
Hemoglobin >= 9.0 g/dL
Total bilirubin =< 1.5 x upper limit of normal (ULN); Note: direct bilirubin and international normalized ratio (INR) for hepatocellular carcinoma (HCC) patients allowed as per Child-Turcotte-Pugh scoring
Alkaline phosphatase =< 2.5 x ULN (=< 5 x ULN if liver metastasis is present or patient is in HCC cohort)
Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) =< 2.5 x ULN (=< 5 x ULN if liver metastasis is present or patient is in HCC cohort)
Creatinine =<1.5 x ULN
Urinalysis < 2+ protein; urine protein should be screened by dipstick or urine analysis; for proteinuria >= 2+, 24-hour urine protein should be obtained and the level should be < 2 g for patient enrollment
Fasting serum cholesterol =< 350 mg/dL (=< 9.0 mmol/L)
Triglycerides =< 1.5 x ULN (mg/dL or mmol/L); patients with triglyceride levels > 1.5 x ULN can be started on lipid lowering agents and reevaluated within 1 week; if levels go to =< 1.5 x ULN, they can be considered for the trial and continue the lipid lowering agents; NOTE: cholesterol and triglyceride measurement and management are not required for single-agent bevacizumab cohort with islet cell carcinoma
International normalized ratio (INR) =< 1.5 (unless the patient is on full dose warfarin)
Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-1
Capable of understanding the investigational nature, potential risks and benefits of the study and able to provide valid informed consent
Negative serum pregnancy test done =< 7 days prior to registration, for women of childbearing potential only; NOTE: patients and their partners should be practicing an effective form of contraception during the study and for at least 3 months following the last dose of this combined therapy
Full-dose anticoagulants, if a patient is receiving full-dose anticoagulants (except carcinoid tumors), the following criteria should be met for enrollment: the subject must have an in-range INR (usually between 2 and 3) on a stable dose of warfarin or on stable dose of low molecular weight (LMW) heparin
Prior systemic treatments for metastatic disease are permitted, including targeted therapies, biologic response modifiers, chemotherapy, hormonal therapy, or investigational therapy; exception: in the case of endometrial cancer no prior chemotherapy for metastatic or recurrent disease is allowed; prior planned adjuvant chemotherapy is allowed
Patients who have had prior anthracycline must have a normal ejection fraction on left ventricular ejection fraction (LVEF) assessment by multigated acquisition scan (MUGA) or echocardiogram (Echo) =< 4 weeks prior to registration
Availability of tissue if applicable (from the primary tumor or metastases) for tumor studies for banking; Note: in the case of hepatocellular cancer if diagnosed by clinical and radiologic criteria only, availability of tissue not applicable
Willingness to donate blood for biomarker studies related to the type of therapies used in this trial and the tumor types being treated
ENDOMETRIAL CANCER (PERMANENTLY CLOSED TO ENROLLMENT)
Any hormonal therapy directed at the malignant tumor is allowed; NOTE: therapy must be discontinued at least one week prior to registration
Prior systemic therapy including biologic and immunologic agents as adjuvant treatment, must be discontinued at least 3 weeks prior to registration
Recurrent or persistent endometrial adenocarcinoma, uterine papillary serous carcinoma and carcinosarcoma which is refractory to curative therapy or established treatments; NOTE: histologic or cytologic confirmation of original primary tumor is required
HEPATOCELLULAR CANCER (PERMANENTLY CLOSED TO ENROLLMENT)
HCC confirmed by biopsy OR diagnosed by clinical and radiologic criteria; all of the following criteria must be met or a biopsy is required:

Known cirrhosis or chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection
Hypervascular liver masses > 2 cm, and either serum alpha-fetoprotein (AFP) > 400 ng/ml, or
AFP > three times normal and doubling in value in the antecedent 3 months
Child-Pugh A (=< 6 points) or better liver status
Prior regional treatments for liver metastasis are permitted including:

Selective internal radiation therapy such as brachytherapy, cyberknife, radiolabeled microsphere embolization, etc.
Hepatic artery chemoembolization
Hepatic artery embolization
Hepatic artery infusional chemotherapy
Radiofrequency ablation NOTE: patients must be >= 4 weeks from treatment and show progressive disease in the liver after regional therapy or must have measurable disease outside the liver
Concomitant anti-viral therapy is allowed
History of prior varices or evidence of varices on pre-study CT/magnetic resonance imaging (MRI) imaging are required to undergo endoscopy =< 4 weeks prior to registration; those who had received specific therapy (banding and/or sclerotherapy) and had not bled within the prior 6 months are eligible
Suitably recovered from prior localized therapy, in the opinion of the investigator
ISLET CELL CANCER AND CARCINOID TUMOR (PERMANENTLY CLOSED TO ENROLLMENT)
Patient has evidence of progressive disease as documented by Response Evaluation Criteria in Solid Tumors (RECIST) =< 7 months prior to study entry
Carcinoid tumor cohort: prior and concurrent long-acting somatostatin analogue therapy is required; patient has to be on a stable dose of a long-acting somatostatin analogue >= 2 months prior to study entry with documentation of progressive disease on current dose
Islet cell tumor cohort: prior and/or concurrent long-acting somatostatin analogue therapy is allowed, but not required; if patient is continued on a long-acting somatostatin analogue, a stable dose for >= 2 months prior to study entry is required with documentation of progressive disease on current dose
Prior therapies allowed include:

=< 2 prior chemotherapy regimens
Prior interferon >= 4 weeks prior to registration
Radiolabeled octreotide therapy (patients with prior radiolabeled octreotide therapy should have progressive disease after such therapy)
Other investigational therapy NOTE: islet Cell Single Agent Bevacizumab Cohort: Prior mammalian target of rapamycin (mTOR) inhibitor is allowed
Prior regional treatments for liver metastasis are permitted including:

Selective internal radiation therapy such as brachytherapy, cyberknife, radiolabeled microsphere embolization, etc.
Hepatic artery chemoembolization
Hepatic artery embolization
Hepatic artery infusional chemotherapy
Radiofrequency ablation NOTE: patients must be >= 12 weeks from treatment and show progressive disease in the liver after regional therapy or must have measurable disease outside the liver

Prior therapy with vascular endothelial growth factor receptor (VEGFR) targeting agents or mammalian target of rapamycin (mTOR) inhibitors (except as in HCC and in the Islet cell single agent bevacizumab alone cohort where prior mTOR inhibitor is allowed); Note: prior use of bevacizumab is not allowed in any cohort
Invasive procedures defined as follows:

Major surgical procedure, open biopsy or significant traumatic injury =< 4 weeks prior to registration
Anticipation of need for major surgical procedures during the course of the study
Core biopsy =< 7 days prior to registration
Serious or non-healing wound, ulcer or bone fracture
History of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess =< 180 days prior to first date of bevacizumab therapy
Evidence of bleeding diathesis or coagulopathy in the absence of therapeutic anticoagulation
Evidence of a history bleeding =< 6 months such as hemoptysis, or cerebrovascular accident =< previous 6 months, or peripheral vascular disease with claudication on < 1 block, or history of clinically significant bleeding, because of the potential bleeding and/or clotting risk with bevacizumab
Untreated central nervous system (CNS) metastases; exceptions: patients with known CNS metastases can be enrolled if the brain metastases have been adequately treated and there is no evidence of progression or hemorrhage after treatment as ascertained by clinical examination and brain imaging (MRI or CT) =< 12 weeks prior to registration and no ongoing requirement for steroids

Anticonvulsants (stable dose) are allowed
Patients who had surgical resection of CNS metastases or brain biopsy =< 3 months prior to registration will be excluded
Significant cardiovascular disease defined as congestive heart failure (New York Heart Association class II, III or IV), angina pectoris requiring nitrate therapy, or recent myocardial infarction (=< 6 months prior to registration)
Uncontrolled hypertension (defined as a blood pressure of >= 150 mmHg systolic and/or >= 90 mmHg diastolic)
Patient is on angiotensin-converting-enzyme (ACE) inhibitors (benazapril, captopril, enalopril, fosonopril, lisinopril, moexipril, perindopril, quinopril, ramipril, and trandolapril); (patients may have an alternate antihypertensive substituted); NOTE: ACE inhibitors are allowed in single agent bevacizumab cohort
Currently active, second malignancy other than non-melanoma skin cancers; NOTE: patients are not considered to have a 'currently active' malignancy if they have completed anti-cancer therapy and are considered by their physician to be at less than 30% risk of relapse
Any of the following, as this regimen may be harmful to a developing fetus or nursing child:

Pregnant women
Breastfeeding women
Men or women of childbearing potential or their sexual partners who are unwilling to employ adequate contraception (diaphragm, birth control pills, injections, intrauterine device [IUD], surgical sterilization, subcutaneous implants, or abstinence, etc.) NOTE: the effects of the agent(s) on the developing human fetus at the recommended therapeutic dose are unknown
Known hypersensitivity to other recombinant human antibodies or Chinese hamster ovary cell products
Other uncontrolled serious medical or psychiatric condition (e.g. cardiac arrhythmias, diabetes, etc.)
Current therapy with a cytochrome P450 3A4 (CYP3A4) inhibitor or inducer; NOTE: these agents are allowed in the single-agent bevacizumab islet cell carcinoma cohort
Active infection requiring antibiotics
Active bleeding or pathological conditions that carry high risk of bleeding (e.g. tumor involving major vessels, known varices)
Known human immunodeficiency virus (HIV)-positive
ENDOMETRIAL CANCER (PERAMANENTLY CLOSED TO ENROLLMENT)
Received prior radiotherapy to any portion of the abdominal cavity or pelvis OTHER THAN for the treatment of endometrial cancer
Any chemotherapy for metastatic or recurrent cancer
Radiation therapy to > 25% of marrow bearing areas
HEPATOCELLULAR CANCER EXCLUSION (PERMANENTLY CLOSED TO ENROLLMENT)
Child-Pugh B or C classification
Grade >= 3 hemorrhage =< 4 weeks prior to registration
Prior liver transplant with evidence of recurrent or metastatic disease
Patients on an active liver transplant list and considered likely to receive a liver transplant =< 6 months following registration
Clinical evidence of encephalopathy
Prior treatment with sorafenib or other vascular endothelial growth factor (VEGF) inhibitors; NOTE: Exceptions allowed for patients unable to tolerate the agent; intolerance is defined in this protocol as a discontinued agent due to side effects with an exposure < to 4 weeks of drug, at any dose level
OVARIAN CANCER (PERMANENTLY CLOSED TO ENROLLMENT)
Clinical signs and symptoms of gastrointestinal (GI) obstruction and require parental hydration/nutrition or tube feeding
Evidence of free abdominal air not explained by paracentesis or recent surgical procedures
Received more than two prior cytotoxic chemotherapy regimens for persistent or recurrent disease
CARCINOID (PERMANENTLY CLOSED TO ENROLLMENT)
Patients on anticoagulant therapy

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Investigators

PRINCIPAL_INVESTIGATOR: Henry Pitot, Mayo Clinic

Publications

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Hobday TJ, Qin R, Reidy-Lagunes D, Moore MJ, Strosberg J, Kaubisch A, Shah M, Kindler HL, Lenz HJ, Chen H, Erlichman C. Multicenter Phase II Trial of Temsirolimus and Bevacizumab in Pancreatic Neuroendocrine Tumors. J Clin Oncol. 2015 May 10;33(14):1551-6. doi: 10.1200/JCO.2014.56.2082. Epub 2014 Dec 8.
Knox JJ, Qin R, Strosberg JR, Tan B, Kaubisch A, El-Khoueiry AB, Bekaii-Saab TS, Rousey SR, Chen HX, Erlichman C. A phase II trial of bevacizumab plus temsirolimus in patients with advanced hepatocellular carcinoma. Invest New Drugs. 2015 Feb;33(1):241-6. doi: 10.1007/s10637-014-0169-3. Epub 2014 Oct 16.

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