PANCREATIC CANCER: DYNAMIC ASSESSMENT AT ALL STAGES OF TREATMENT

Study Overview

The study consists of a 25 ml blood sample collection: * Before the start of treatment * Approximately 2 months after the start of induction chemotherapy * At the end of induction chemotherapy * Prior to local treatment (radiotherapy, surgery) * At the time of tumor progression Collection of tumor material: * During the initial diagnostic biopsy * On the operating room in case of surgery * At tumor biopsy in case of recurrence or progression (optional) As well as the completion of a questionnaire at inclusion.

N/A

Pancreatic Cancer Non-resectable

OTHER: collection of blood and tumor samples

PANDORE-PANC-IPC 2021-082

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates	Results Reporting Dates	Study Record Updates
First Submitted 2022-11-23	Results First Submitted N/A	Last Update Submitted that met QC Criteria 2023-03-27
First Submitted that Met QC Criteria 2023-03-27	Results First Submitted that Met QC Criteria N/A	Last Update Posted (ACTUAL) 2023-04-06
First Posted (ACTUAL) 2023-04-06	Results First Posted N/A	Last Verified 2023-03

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

Primary Purpose:
Other

Allocation:
Na

Interventional Model:
Single Group

Masking:
None

Arms and Interventions

Participant Group/Arm	Intervention/Treatment
OTHER: collection of blood and tumor samples	OTHER: collection of blood and tumor samples The study consists of the collection of a 25 ml blood sample: * Before the start of treatment * Approximately 2 months after the start of induction chemotherapy * At the end of induction chemotherapy * Prior to local treatment (radiotherapy, surgery) * A

Participant Group/Arm

Intervention/Treatment

OTHER: collection of blood and tumor samples

The study consists of the collection of a 25 ml blood sample: * Before the start of treatment * Approximately 2 months after the start of induction chemotherapy * At the end of induction chemotherapy * Prior to local treatment (radiotherapy, surgery) * A

Primary Outcome Measures	Measure Description	Time Frame
Predict response to systemic therapies in patients with non-metastatic pancreatic adenocarcinoma	Analysis of the impact of identified biomarkers on overall patient survival and tumour response	up to 6 years

Secondary Outcome Measures	Measure Description	Time Frame

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Dominique GENRE, MD

Phone Number: +33491223778

Email: drci.up@ipc.unicancer.fr

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person’s general health condition or prior treatments.

Ages Eligible for Study:
ALL

Sexes Eligible for Study:
18 Years

Accepts Healthy Volunteers:

Non-metastatic pancreatic adenocarcinoma that is not immediately resectable (borderline and locally advanced tumors according to the NCCN 2020 classification)
No previous treatment with surgery or chemotherapy
Age > 18 years
General condition WHO 0-2 (patient whose general condition can allow medical treatment or surgery)
Therapeutic management at the Paoli-Calmettes Institute
Signature of the informed consent specific to the PANDORE-PANC study
Patient affiliated to a social security system or benefiting from such a system

Metastatic disease
Pancreatic tumor of a histological type other than adenocarcinoma
Other tumor under treatment or for which treatments have been completed for < 1 year
Pregnant or breastfeeding women
Person in an emergency situation
Person of legal age under legal protection (guardianship, curatorship or safeguard of justice) or unable to give consent.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Publications

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

No publications available

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Clinical Trial Record