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Correlation Between Elastic Modulus of Ultrasonic Shear Wave and Tumor Stromal Component in Pancreatic Cancer


2022-02-01


2022-10-01


2022-10-01


50

Study Overview

Correlation Between Elastic Modulus of Ultrasonic Shear Wave and Tumor Stromal Component in Pancreatic Cancer

Pancreatic cancer is a gastrointestinal tumor with a high degree of malignancy. Currently, there are many first-line chemotherapy regimens in clinical practice, but the individual selection of chemotherapy regimens has not been unanimously recognized.This study is aimed at exploring the correlation between the two-dimensional shear wave elastography (2D - SWE) parameters and pancreatic cancer stromal elements proportion through an ultrasound scan for resectable pancreatic cancer cases and postoperative pathological specimen analysis. Then determine if the pancreatic cancer two-dimensional shear wave elastography can guide clinicians selecting chemotherapy scheme by predicting tumor stromal elements .These results are expected to provide an effective non-invasive diagnostic basis for individualized treatment of pancreatic cancer.

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  • Pancreatic Neoplasms
  • DIAGNOSTIC_TEST: two-dimensional shear wave elastography
  • KY20212175-C-1

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates Results Reporting Dates Study Record Updates

2021-12-20  

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2022-01-16  

2022-01-09  

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2022-01-19  

2022-01-11  

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2021-10  

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

Primary Purpose:
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Allocation:
N/A


Interventional Model:
N/A


Masking:
N/A


Arms and Interventions

Participant Group/ArmIntervention/Treatment
Primary Outcome MeasuresMeasure DescriptionTime Frame
Elastic modulus measured by Ultrasonic shear wave and tumor stromal component assessed by pathological analysis in pancreatic cancerBaseline (Preoperative ultrasound elastography examination)
Secondary Outcome MeasuresMeasure DescriptionTime Frame

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Kunlong Duan

Phone Number: +8617795629885

Email: 804868814@qq.com

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person’s general health condition or prior treatments.

Ages Eligible for Study:
ALL

Sexes Eligible for Study:
18 Years

Accepts Healthy Volunteers:

    Inclusion Criteria
    1. Patients with resectable pancreatic cancer underwent ultrasound examination before surgery 2. Conventional ultrasound can clearly show pancreatic space-occupying lesions and the elastic measurements show good images 3. The patient agrees to receive ultrasound elasticity examination and signs informed consent 4. All patients had no history of radiotherapy or chemotherapy before ultrasound examination 5. All clinical case data and auxiliary examination data are complete and accessible.
    Exclusion Criteria
    1. Ultrasound evaluation was not performed before ultrasound-guided needle biopsy 2. Conventional ultrasound could not clearly show pancreatic space-occupying lesions or poor elastic measurement images 3. Patients who refuse to accept examination or give up treatment 4. Patients receiving neoadjuvant chemotherapy or radiotherapy before ultrasound examination 5. Incomplete clinical data and auxiliary examination data.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Publications

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General Publications

No publications available