Clinical Trial Record

Return to Clinical Trials

Cancer Development In Organ Transplant Recipients


2008-05


2018-05


2019-07


1800

Study Overview

Cancer Development In Organ Transplant Recipients

The investigators will determine the cancer risk in organ transplant recipients compared to the general population with the help of statistical analysis. Secondly the investigators will try to characterize the different cancer types.

This cohort analyses will focus on incident and recurrent cases of development of non-skin cancer over time. We will consider time to first formation of non-skin solid cancer after solid organ transplantation as well as the cumulative number of non-skin solid cancer formation over time. Both aspects are equally important and will be reflected in the analytic methods of this study. Theses analyses will be restricted to the most prevalent transplantation types of heart, kidney, liver, and lung.

  • Heart Cancer
  • Kidney Cancer
  • Lung Cancer
  • Pancreas Cancer
  • Liver Cancer
    • FUP062
    • snctp000000587 (OTHER Identifier) (OTHER: Swiss National Clinical Trials Portal)

    Study Record Dates

    These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

    Study Registration Dates Results Reporting Dates Study Record Updates

    2014-12-18  

    N/A  

    2019-07-25  

    2015-01-05  

    N/A  

    2019-07-29  

    2015-01-07  

    N/A  

    2019-07  

    Study Plan

    This section provides details of the study plan, including how the study is designed and what the study is measuring.

    Design Details

    Primary Purpose:
    N/A


    Allocation:
    N/A


    Interventional Model:
    N/A


    Masking:
    N/A


    Arms and Interventions

    Participant Group/ArmIntervention/Treatment
    : Organ transplant recipients

    Follow-ups in regular intervals following the organ transplant date.

    Primary Outcome MeasuresMeasure DescriptionTime Frame
    Number of solid cancersNumber of solid cancersTen Year followup
    Secondary Outcome MeasuresMeasure DescriptionTime Frame

    Contacts and Locations

    This section provides the contact details for those conducting the study, and information on where this study is being conducted.

    Participation Criteria

    Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person’s general health condition or prior treatments.

    Ages Eligible for Study:
    ALL

    Sexes Eligible for Study:

    Accepts Healthy Volunteers:

      Inclusion Criteria:
      We will select all patients within the STCS based on the date of the first solid organ transplantation. Patients with multiple organ transplantations will be included as well. Patients contribute to the study observation time until death or end of follow-up due to other reasons.
      Exclusion Criteria:
      We will exclude patients with non-solid organ transplantation (e.g. hematopoietic stem cell transplantation), because the detailing of information in the STCS is insufficient to allow for detailed analysis of cancer development and control of relevant confounders. We will exclude

    Collaborators and Investigators

    This is where you will find people and organizations involved with this study.

    • University Hospital, Basel, Switzerland
    • Insel Gruppe AG, University Hospital Bern
    • Cantonal Hospital of St. Gallen
    • University Hospital, Geneva
    • University of Lausanne Hospitals

    • PRINCIPAL_INVESTIGATOR: Gunther FL Hofbauer, MD, University Hospital, Zürich

    Publications

    The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

    General Publications

    • Lengwiler E, Stampf S, Zippelius A, Salati E, Zaman K, Schafer N, Schardt J, Siano M, Hofbauer G, The Swiss Transplant Cohort Study. Solid cancer development in solid organ transplant recipients within the Swiss Transplant Cohort Study. Swiss Med Wkly. 2019 May 19;149:w20078. doi: 10.4414/smw.2019.20078. eCollection 2019 May 6.