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2025-08-31
2026-06-30
2027-07-31
600
NCT07136701
Qilu Hospital of Shandong University
Qilu Hospital of Shandong University
OBSERVATIONAL
Risk Factors, Prognosis, Clinicopathological and Metabolic Characteristics of EO- vs LO-PanNETs
The aim of this observational multicenter retrospective cohort study is to evaluate the differences in risk factors, prognosis, clinicopathological and metabolic characteristics between early-onset pancreatic neuroendocrine tumors (EO-PanNETs) and late-onset pancreatic neuroendocrine tumors (LO-PanNETs). The main questions it aims to answer are: Are there distinct clinical, pathological, and metabolic profiles in EO-PanNETs compared with LO-PanNETs? Do EO-PanNETs have different prognostic outcomes compared with LO-PanNETs? Researchers will compare EO-PanNET patients with LO-PanNET patients and with matched nonmalignant controls to assess differences in tumor characteristics and associated metabolic conditions. Participants will: Provide retrospective clinical, pathological, and metabolic data from hospital records. Have survival and recurrence outcomes assessed through follow-up data review.
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These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
| Study Registration Dates | Results Reporting Dates | Study Record Updates |
|---|---|---|
2025-08-14 | N/A | 2025-08-21 |
2025-08-21 | N/A | 2025-08-22 |
2025-08-22 | N/A | 2025-08 |
This section provides details of the study plan, including how the study is designed and what the study is measuring.
Primary Purpose:
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Allocation:
N/A
Interventional Model:
N/A
Masking:
N/A
Arms and Interventions
| Participant Group/Arm | Intervention/Treatment |
|---|---|
| : Early-onset pancreatic neuroendocrine tumors group This group comprises patients diagnosed with pancreatic neuroendocrine tumors before the age of 50 years. All cases were histopathologically confirmed and treated at one of the participating centers. | |
| : Late-onset pancreatic neuroendocrine tumors group This group comprises patients diagnosed with pancreatic neuroendocrine tumors at or after the age of 50 years. All cases were histopathologically confirmed and treated at one of the participating centers. |
| Primary Outcome Measures | Measure Description | Time Frame |
|---|---|---|
| Overall Survival | From date of randomization until the date of death from any cause or the date of the last follow-up, whichever came first, assessed up to 12 years |
| Secondary Outcome Measures | Measure Description | Time Frame |
|---|---|---|
| Disease-specific survival | From date of diagnosis until death due to PanNETs, up to 12 years | |
| Progression-free survival | From date of diagnosis until the date of disease recurrence or death from any cause, whichever came first, assessed up to 12 years. | |
| Disease-free survival | From date of surgery until first documented recurrence, metastasis, or death from any cause, assessed up to 12 years. |
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
|
Study Contact Name: Hanxiang Zhan, MD. PhD. Phone Number: +86 18560085156 Email: zhanhanxiang@hotmail.com |
Study Contact Backup Name: Changhao Gao, MMed Phone Number: Email: gaochanghao44@gmail.com |
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person’s general health condition or prior treatments.
Ages Eligible for Study:
ALL
Sexes Eligible for Study:
18 Years
Accepts Healthy Volunteers:
This is where you will find people and organizations involved with this study.
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
No publications available
