Survival Among Patients With Pancreatic Cancer Depending On Surgical Resection Rate

Study Overview

Survival Among Patients With Pancreatic Cancer Depending on Surgical Resection Rate

The primary aim of this population-based study is to investigate how a high resection rate of pancreaticoduodenectomy affects overall survival among patients aged ≥70 years with pancreatic ductal adenocarcinoma. The secondary aim is to determine if a high resection rate of pancreaticoduodenectomy increases perioperative morbidity.

N/A

Pancreatic Ductal Adenocarcinoma

OTHER: Resection rates

2017/151-31

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates	Results Reporting Dates	Study Record Updates
First Submitted 2021-03-15	Results First Submitted N/A	Last Update Submitted that met QC Criteria 2021-03-15
First Submitted that Met QC Criteria 2021-03-15	Results First Submitted that Met QC Criteria N/A	Last Update Posted (ACTUAL) 2021-03-17
First Posted (ACTUAL) 2021-03-17	Results First Posted N/A	Last Verified 2021-03

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

Primary Purpose:
N/A

Allocation:
N/A

Interventional Model:
N/A

Masking:
N/A

Arms and Interventions

Participant Group/Arm	Intervention/Treatment
: All patients with pancreatic ductal adenocarcinoma aged 70 years and older All patients in the registry aged 70 years and older with right-sided pancreatic ductal adenocarcinoma
: All patients with pancreatic ductal adenocarcinoma aged 70-79 years All patients in the registry aged 70-79 years with right-sided pancreatic ductal adenocarcinoma
: All patients with pancreatic ductal adenocarcinoma aged 80 years and older All patients in the registry aged 80 years and older with right-sided pancreatic ductal adenocarcinoma
: All patients resected with pancreaticoduodenectomy, all ages All patients in the registry resected with pancreaticoduodenectomy during the study period	OTHER: Resection rates All groups are divided into one high- and one low resection rate group depending on percentage of patients with pancreatic ductal adenocarcinoma resected per county and year (first three groups) and resection rate of pancreaticoduodenectomy per 100 000 in
: All patients resected with pancreaticoduodenectomy, aged 70-79 years All patients in the registry resected with pancreaticoduodenectomy during the study period, aged 70-79 years	OTHER: Resection rates All groups are divided into one high- and one low resection rate group depending on percentage of patients with pancreatic ductal adenocarcinoma resected per county and year (first three groups) and resection rate of pancreaticoduodenectomy per 100 000 in
: All patients resected with pancreaticoduodenectomy, aged 80 years and older All patients in the registry resected with pancreaticoduodenectomy during the study period, aged 80 years and older	OTHER: Resection rates All groups are divided into one high- and one low resection rate group depending on percentage of patients with pancreatic ductal adenocarcinoma resected per county and year (first three groups) and resection rate of pancreaticoduodenectomy per 100 000 in

Primary Outcome Measures	Measure Description	Time Frame
Overall survival	Overall survival among patients aged 70 years and over with pancreatic ductal adenocarcinoma in the pancreatic head	A little more than 10 years (from first patient to vital status)

Secondary Outcome Measures	Measure Description	Time Frame
Severe complications after pancreaticoduodenectomy	The rate of severe complications among patients aged 70 years and over who had undergone pancreaticoduodenectomy for any reason	Around 10 years (patients diagnosed between 1 January 2010 and 31 December 2018, latest dismissal from hospital january 2020)

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person’s general health condition or prior treatments.

Ages Eligible for Study:
ALL

Sexes Eligible for Study:

Accepts Healthy Volunteers:

Diagnosed between 1 January 2010 and 31 December 2018
Registered in the Swedish National Registry for tumours in the pancreatic and periampullary region
Either a diagnosis of pancreatic ductal adenocarcinoma of the pancreatic head or having been resected with pancreaticoduodenectomy

None

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Publications

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

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Clinical Trial Record